ExPASy Proteomics Server

HPI The UniProtKB/Swiss-Prot Human Proteome Initiative

The HPI program stopped in November 2008 after the release of the first complete set of human proteins. This annotation program has been replaced by the program CD2 (Core Data for Chordata).

The Human Proteome Initiative (HPI) aims to annotate all known human protein sequences, as well as their orthologous sequences in other mammals, according to the quality standards of UniProtKB/Swiss-Prot. In addition to accurate sequences, we strive to provide, for each protein, a wealth of information that includes the description of its function, domain structure, subcellular location, similarities to other proteins, etc.

About 21'000 human genes encode one million different proteins.

In the annotation process, special emphasis is given to the generation of high levels of protein diversity (PubMed: 16286078). These are mainly generated by alternative splicing and post-translational modifications (PTMs). Polymorphisms are also reported as they provide links between genotypes and diseases as well as other complex phenotypes. Numerous cross-references are made to specialized databases, such as OMIM, HGNC and H-InvDB, as well as to the PDB/RCSB 3D-structure database.

Chromosome pages